Engaging with Sensitivity: Techniques for (Brief Explanation) Interviewing Persons Experiencing Homelessness, Disability, and Substance Use Disorders is an introductory-level course designed for case interviewers, disease intervention specialists, and others at state, tribal, local, and territorial public health agencies who collect data for infectious diseases and other public health purposes. This training focuses on the importance of accurately capturing data on disproportionately affected populations during public health case investigations, with a focus on persons experiencing homelessness, persons with disabilities, and persons with substance use disorders. Over a series of six lessons and a final case study, we will discuss what is meant by disproportionately affected populations, the role of implicit bias and cultural humility in case investigations, general techniques for building and maintaining rapport, and how to discuss potentially sensitive topics.